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Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches
المؤلفون المشاركون
Lu, Juan
Lyu, Xinkai
Chai, Ruiping
Yu, Yue
Deng, Minghui
Zhan, Xia
Dong, Zhengqi
Chen, Xi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Shengmai injection (SMI) contains Ginsen Radix et Rhizoma Rubra, Ophiopogon japonicus, and Schisandrae Chinensis Fructus.
It is used as a supportive herbal medicine in the management of sepsis, systemic inflammatory response syndrome, and septic or hemorrhagic shock.
An UPLC method was established to identify and evaluate SMI fingerprints.
Fingerprint similarities of 9 batches of SMI were compared.
The network platform, “TCM-components-core targets-key pathways,” was established, and the mechanism of SMI in the treatment of sepsis was investigated.
The similarity of 9 batches of SMI fingerprints was greater than 0.91.
44 peaks were selected as the common peaks, of which 11 peaks were identified.
KEGG functional pathway analysis showed SMI was mainly involved in the pathways of cancer, cell cycle, and p53 signaling, suggesting SMI protects multiple organs via regulating immunity, inflammation, apoptosis, and energy metabolism.
GO enrichment analysis showed active SMI components regulated various biological processes and altered the pathophysiology of sepsis.
The interplays between SMI and multiple energy metabolism signaling cascades confer protection from life-threatening multiple organ failure in sepsis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Juan& Lyu, Xinkai& Chai, Ruiping& Yu, Yue& Deng, Minghui& Zhan, Xia…[et al.]. 2020. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156348
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Juan…[et al.]. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1156348
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Juan& Lyu, Xinkai& Chai, Ruiping& Yu, Yue& Deng, Minghui& Zhan, Xia…[et al.]. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156348
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156348
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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