Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches
Joint Authors
Lu, Juan
Lyu, Xinkai
Chai, Ruiping
Yu, Yue
Deng, Minghui
Zhan, Xia
Dong, Zhengqi
Chen, Xi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Shengmai injection (SMI) contains Ginsen Radix et Rhizoma Rubra, Ophiopogon japonicus, and Schisandrae Chinensis Fructus.
It is used as a supportive herbal medicine in the management of sepsis, systemic inflammatory response syndrome, and septic or hemorrhagic shock.
An UPLC method was established to identify and evaluate SMI fingerprints.
Fingerprint similarities of 9 batches of SMI were compared.
The network platform, “TCM-components-core targets-key pathways,” was established, and the mechanism of SMI in the treatment of sepsis was investigated.
The similarity of 9 batches of SMI fingerprints was greater than 0.91.
44 peaks were selected as the common peaks, of which 11 peaks were identified.
KEGG functional pathway analysis showed SMI was mainly involved in the pathways of cancer, cell cycle, and p53 signaling, suggesting SMI protects multiple organs via regulating immunity, inflammation, apoptosis, and energy metabolism.
GO enrichment analysis showed active SMI components regulated various biological processes and altered the pathophysiology of sepsis.
The interplays between SMI and multiple energy metabolism signaling cascades confer protection from life-threatening multiple organ failure in sepsis.
American Psychological Association (APA)
Lu, Juan& Lyu, Xinkai& Chai, Ruiping& Yu, Yue& Deng, Minghui& Zhan, Xia…[et al.]. 2020. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156348
Modern Language Association (MLA)
Lu, Juan…[et al.]. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1156348
American Medical Association (AMA)
Lu, Juan& Lyu, Xinkai& Chai, Ruiping& Yu, Yue& Deng, Minghui& Zhan, Xia…[et al.]. Investigation of the Mechanism of Shengmai Injection on Sepsis by Network Pharmacology Approaches. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1156348
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156348