Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines
المؤلفون المشاركون
Jiang, Haiqiang
Cui, Qinghua
Gong, Lili
Yang, Yong
Kang, Qianli
Wang, Yanyan
Rong, Rong
Du, Ruikun
Rong, Lijun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicines (TCMs) have proven to possess advantages in counteracting virus infections according to clinical practices.
It’s therefore of great value to discover novel antivirals from TCMs.
In this paper, One hundred medicinal plants which have been included in TCM prescriptions for antiviral treatment were selected and prefractionated into 5 fractions each by sequentially using cyclohexane, dichloromethane, ethyl acetate, n-butanol, and water.
500 TCM-simplified extracts were then subjected to a phenotypic screening using a recombinant IAV expressing Gaussia luciferase.
Ten TCM fractions were identified to possess antiviral activities against influenza virus.
The IC50’s of the hit fractions range from 1.08 to 6.45 μg/mL, while the SIs, from 7.52 to 98.40.
Furthermore, all the ten hit fractions inhibited the propagation of progeny influenza virus significantly at 20 μg/mL.
The hit TCM fractions deserve further isolation for responsible constituents leading towards anti-influenza drugs.
Moreover, a library consisting of 500 simplified TCM extracts was established, facilitating antiviral screening in quick response to emerging and re-emerging viruses such as Ebola virus and current SARS-CoV-2 pandemic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Qianli& Wang, Yanyan& Cui, Qinghua& Gong, Lili& Yang, Yong& Jiang, Haiqiang…[et al.]. 2020. Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Qianli…[et al.]. Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1156351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Qianli& Wang, Yanyan& Cui, Qinghua& Gong, Lili& Yang, Yong& Jiang, Haiqiang…[et al.]. Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر