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Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines
Joint Authors
Jiang, Haiqiang
Cui, Qinghua
Gong, Lili
Yang, Yong
Kang, Qianli
Wang, Yanyan
Rong, Rong
Du, Ruikun
Rong, Lijun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Traditional Chinese medicines (TCMs) have proven to possess advantages in counteracting virus infections according to clinical practices.
It’s therefore of great value to discover novel antivirals from TCMs.
In this paper, One hundred medicinal plants which have been included in TCM prescriptions for antiviral treatment were selected and prefractionated into 5 fractions each by sequentially using cyclohexane, dichloromethane, ethyl acetate, n-butanol, and water.
500 TCM-simplified extracts were then subjected to a phenotypic screening using a recombinant IAV expressing Gaussia luciferase.
Ten TCM fractions were identified to possess antiviral activities against influenza virus.
The IC50’s of the hit fractions range from 1.08 to 6.45 μg/mL, while the SIs, from 7.52 to 98.40.
Furthermore, all the ten hit fractions inhibited the propagation of progeny influenza virus significantly at 20 μg/mL.
The hit TCM fractions deserve further isolation for responsible constituents leading towards anti-influenza drugs.
Moreover, a library consisting of 500 simplified TCM extracts was established, facilitating antiviral screening in quick response to emerging and re-emerging viruses such as Ebola virus and current SARS-CoV-2 pandemic.
American Psychological Association (APA)
Kang, Qianli& Wang, Yanyan& Cui, Qinghua& Gong, Lili& Yang, Yong& Jiang, Haiqiang…[et al.]. 2020. Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156351
Modern Language Association (MLA)
Kang, Qianli…[et al.]. Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1156351
American Medical Association (AMA)
Kang, Qianli& Wang, Yanyan& Cui, Qinghua& Gong, Lili& Yang, Yong& Jiang, Haiqiang…[et al.]. Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1156351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156351