Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats
المؤلفون المشاركون
Herrera-Calderon, Oscar
Rojas-Armas, Juan Pedro
Arroyo-Acevedo, Jorge Luis
Ortiz-Sánchez, José Manuel
Palomino-Pacheco, Miriam
Calva, James
Rojas-Armas, Agustín
Justil-Guerrero, Hugo Jesús
Castro-Luna, Américo
Hilario-Vargas, Julio
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective of this study was to evaluate the chemopreventive effect of the ethanolic extract of Cordia lutea flowers (EECL) on N-methyl-N-nitrosourea- (MNU), cyproterone-, and testosterone-induced prostate cancer in rats.
40 Holtzman male rats were used and assigned to 5 groups (n = 8).
In Group I, rats received normal saline (10 mL/Kg); Group II: rats were induced for prostate cancer with cyproterone, testosterone, and NMU; Groups III, IV, and V: rats received EECL daily, at doses of 50, 250, and 500 mg/kg body weight, respectively.
After the period of treatment, animals were sacrificed by an overdose of pentobarbital and blood samples were collected for determination of prostate-specific antigen (PSA).
The prostate was dissected and weighed accurately.
The ventral lobe of the prostate was processed for histopathology analysis.
The somatic prostate index decreased with EECL at dependent dose, from 0.34 ± 0.04 to 0.23 ± 0.05 (P<0.05).
The PSA levels also decreased significantly at doses of 250 and 500 mg/kg.
Histopathological analysis showed a decrease in the number of prostatic layers with high-grade prostatic intraepithelial neoplasia (HG-PIN) and low-grade prostatic intraepithelial neoplasia (LG-PIN) at the dose of 500 mg/kg.
The ethanolic extract of Cordia lutea flowers had a chemopreventive effect on induced prostate cancer in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rojas-Armas, Juan Pedro& Arroyo-Acevedo, Jorge Luis& Ortiz-Sánchez, José Manuel& Palomino-Pacheco, Miriam& Herrera-Calderon, Oscar& Calva, James…[et al.]. 2020. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156387
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rojas-Armas, Juan Pedro…[et al.]. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156387
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rojas-Armas, Juan Pedro& Arroyo-Acevedo, Jorge Luis& Ortiz-Sánchez, José Manuel& Palomino-Pacheco, Miriam& Herrera-Calderon, Oscar& Calva, James…[et al.]. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156387
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156387
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر