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Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats
Joint Authors
Herrera-Calderon, Oscar
Rojas-Armas, Juan Pedro
Arroyo-Acevedo, Jorge Luis
Ortiz-Sánchez, José Manuel
Palomino-Pacheco, Miriam
Calva, James
Rojas-Armas, Agustín
Justil-Guerrero, Hugo Jesús
Castro-Luna, Américo
Hilario-Vargas, Julio
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The objective of this study was to evaluate the chemopreventive effect of the ethanolic extract of Cordia lutea flowers (EECL) on N-methyl-N-nitrosourea- (MNU), cyproterone-, and testosterone-induced prostate cancer in rats.
40 Holtzman male rats were used and assigned to 5 groups (n = 8).
In Group I, rats received normal saline (10 mL/Kg); Group II: rats were induced for prostate cancer with cyproterone, testosterone, and NMU; Groups III, IV, and V: rats received EECL daily, at doses of 50, 250, and 500 mg/kg body weight, respectively.
After the period of treatment, animals were sacrificed by an overdose of pentobarbital and blood samples were collected for determination of prostate-specific antigen (PSA).
The prostate was dissected and weighed accurately.
The ventral lobe of the prostate was processed for histopathology analysis.
The somatic prostate index decreased with EECL at dependent dose, from 0.34 ± 0.04 to 0.23 ± 0.05 (P<0.05).
The PSA levels also decreased significantly at doses of 250 and 500 mg/kg.
Histopathological analysis showed a decrease in the number of prostatic layers with high-grade prostatic intraepithelial neoplasia (HG-PIN) and low-grade prostatic intraepithelial neoplasia (LG-PIN) at the dose of 500 mg/kg.
The ethanolic extract of Cordia lutea flowers had a chemopreventive effect on induced prostate cancer in rats.
American Psychological Association (APA)
Rojas-Armas, Juan Pedro& Arroyo-Acevedo, Jorge Luis& Ortiz-Sánchez, José Manuel& Palomino-Pacheco, Miriam& Herrera-Calderon, Oscar& Calva, James…[et al.]. 2020. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156387
Modern Language Association (MLA)
Rojas-Armas, Juan Pedro…[et al.]. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156387
American Medical Association (AMA)
Rojas-Armas, Juan Pedro& Arroyo-Acevedo, Jorge Luis& Ortiz-Sánchez, José Manuel& Palomino-Pacheco, Miriam& Herrera-Calderon, Oscar& Calva, James…[et al.]. Cordia lutea L. Flowers: A Promising Medicinal Plant as Chemopreventive in Induced Prostate Carcinogenesis in Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156387