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Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways
المؤلفون المشاركون
Meng, Yong
Meng, Ke
Zhao, Xin
Li, Donghua
Gao, Qiaoying
Wu, Shangwei
Cui, Yunfeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The study attempted to elucidate whether lipid genes are closely associated with lipid metabolic abnormalities during the lithogenic time and how Yinchenhao Decoction (YCHD) works on the transcriptions of lipid genes against cholesterol gallstone model.
C57BL/6J mice fed on lithogenic diet (LD) were used for model establishment and randomized into 5 groups.
All groups received LD for different weeks with isometrically intragastric administration of YCHD or NS.
Biochemical tests were measured and liver tissues were harvested for histological and genetic detection.
It was found that all groups with increasing LD showed a following tendency of gallstone incidence, bile cholesterol, phospholipids, total bile acid, and cholesterol saturation index (CSI).
Conversely, YCHD could significantly normalize the levels of gallstone incidence, bile lipids, and CSI (CSI<1).
As lithogenic time progressed, ABCG5, ABCG8, PPAR-α, and ABCB4 were upregulated, and SREBP2, CYP7A1, and CYP7B1 were downregulated, while CYP7A1, CYP7B1, LXR, and HMGCR mRNA were increased 3-fold under the administration of YCHD.
It was concluded that abnormal expressions of the mentioned genes may eventually progress to cholesterol gallstone.
CYP7A1, CYP7B1, LXR, and HMGCR mRNA may be efficient targets of YCHD, which may be a preventive drug to reverse liver injury, normalize bile lipids, facilitate gallstone dissolution, and attenuate gallstone formation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Meng, Yong& Meng, Ke& Zhao, Xin& Li, Donghua& Gao, Qiaoying& Wu, Shangwei…[et al.]. 2018. Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156434
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Meng, Yong…[et al.]. Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156434
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Meng, Yong& Meng, Ke& Zhao, Xin& Li, Donghua& Gao, Qiaoying& Wu, Shangwei…[et al.]. Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156434
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156434
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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