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Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways
Joint Authors
Meng, Yong
Meng, Ke
Zhao, Xin
Li, Donghua
Gao, Qiaoying
Wu, Shangwei
Cui, Yunfeng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The study attempted to elucidate whether lipid genes are closely associated with lipid metabolic abnormalities during the lithogenic time and how Yinchenhao Decoction (YCHD) works on the transcriptions of lipid genes against cholesterol gallstone model.
C57BL/6J mice fed on lithogenic diet (LD) were used for model establishment and randomized into 5 groups.
All groups received LD for different weeks with isometrically intragastric administration of YCHD or NS.
Biochemical tests were measured and liver tissues were harvested for histological and genetic detection.
It was found that all groups with increasing LD showed a following tendency of gallstone incidence, bile cholesterol, phospholipids, total bile acid, and cholesterol saturation index (CSI).
Conversely, YCHD could significantly normalize the levels of gallstone incidence, bile lipids, and CSI (CSI<1).
As lithogenic time progressed, ABCG5, ABCG8, PPAR-α, and ABCB4 were upregulated, and SREBP2, CYP7A1, and CYP7B1 were downregulated, while CYP7A1, CYP7B1, LXR, and HMGCR mRNA were increased 3-fold under the administration of YCHD.
It was concluded that abnormal expressions of the mentioned genes may eventually progress to cholesterol gallstone.
CYP7A1, CYP7B1, LXR, and HMGCR mRNA may be efficient targets of YCHD, which may be a preventive drug to reverse liver injury, normalize bile lipids, facilitate gallstone dissolution, and attenuate gallstone formation.
American Psychological Association (APA)
Meng, Yong& Meng, Ke& Zhao, Xin& Li, Donghua& Gao, Qiaoying& Wu, Shangwei…[et al.]. 2018. Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156434
Modern Language Association (MLA)
Meng, Yong…[et al.]. Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156434
American Medical Association (AMA)
Meng, Yong& Meng, Ke& Zhao, Xin& Li, Donghua& Gao, Qiaoying& Wu, Shangwei…[et al.]. Protective Effects of Yinchenhao Decoction on Cholesterol Gallstone in Mice Fed a Lithogenic Diet by Regulating LXR, CYP7A1, CYP7B1, and HMGCR Pathways. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156434