T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity
المؤلفون المشاركون
Principi, Mariabeatrice
Losurdo, Giuseppe
Ierardi, Enzo
Di Leo, Alfredo
Iannone, Andrea
Piscitelli, Domenico
Pezzuto, Federica
Fortarezza, Francesco
Covelli, Claudia
Marra, Antonella
Amoruso, Annacinzia
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background and Aims.
Nonceliac gluten sensitivity (NCGS) is a gluten-related emerging condition.
Since few data about NCGS histopathology is available, we assessed the markers of lymphocyte and innate immunity activation.
Materials and Methods.
We retrieved duodenal biopsy samples of patients with NCGS diagnosis according to the Salerno criteria.
We selected specimens of positive (seropositive celiac disease/Marsh 1-2 stage) and negative (normal microscopic picture) controls.
Immunohistochemistry for CD3 (intraepithelial lymphocytes-IELs), CD4 (T helper lymphocytes), CD8 (T cytotoxic lymphocytes), and CD1a/CD117 (Langerhans/mast cells) was performed.
ANOVA plus Bonferroni’s tests were used for statistical analysis.
Results.
Twenty NCGS, 16 celiac disease, and 16 negative controls were selected.
CD3 in NCGS were higher than negative controls and lower than celiac disease (18.5 ± 6.4, 11.9 ± 2.8, and 40.8 ± 8.1 IELs/100 enterocytes; p<0.001).
CD4 were lower in NCGS than controls and celiac disease (31.0 ± 22.1, 72.5 ± 29.5, and 103.7 ± 15.7 cells/mm2; p<0.001).
CD8 in NCGS were similar to negative controls, but lower than celiac disease (14.0 ± 7.4 and 34.0 ± 7.1 IELs/100 enterocytes, p<0.001).
CD117 were higher in NCGS than celiac disease and negative controls (145.8 ± 49.9, 121.3 ± 13.1, and 113.5 ± 23.4 cells/mm2; p=0.009).
Conclusions.
The combination of CD4 and CD117, as well as IEL characterization, may be useful to support a clinical diagnosis of NCGS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Losurdo, Giuseppe& Piscitelli, Domenico& Pezzuto, Federica& Fortarezza, Francesco& Covelli, Claudia& Marra, Antonella…[et al.]. 2017. T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Losurdo, Giuseppe…[et al.]. T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity. Gastroenterology Research and Practice No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1156436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Losurdo, Giuseppe& Piscitelli, Domenico& Pezzuto, Federica& Fortarezza, Francesco& Covelli, Claudia& Marra, Antonella…[et al.]. T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1156436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر