The Protective Effect of Different Polar Solvent Extracts of Er Miao San on Rats with Adjuvant Arthritis
المؤلفون المشاركون
Zhang, Wei
Zhang, Qiying
Xuan, Zihua
Liang, Juan
Yang, Dongping
Ding, Meihuizi
Zhu, Housheng
Su, Bo
Dai, Xing
Jia, Xiaoyi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study was to evaluate the antiarthritic effects of different polar solvent extracts of Er Miao San (EMS) on model rats with adjuvant arthritis (AA) and screen the effective pats of EMS in the treatment of arthritis.
Methods.
Four different polar solvent extracts of EMS such as petroleum ether (PE), methylene chloride (CH2Cl2), ethyl acetate (EtOAc), and n-butanol (n-BuOH) were extracted and separated by different solvent polar extraction.
Different polar parts of the aqueous extract of EMS were orally administered for 14 days to AA rats.
Progression of clinical signs such as edema of paws and polyarthritis index was measured.
The ankle joint changes were observed by pathological sections.
ELISA was used to measure cytokines in the serum according to the manufacturer’s instructions.
UHPLC measured the effective parts of EMS.
Results.
Administration of EtOAc and CH2Cl2 parts remarkably inhibited the paw swelling, decreased the index of arthritis, decreased the body weight loss, and improved the changes of histopathology.
Furthermore, the concentrations of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) were significantly lower, while the anti-inflammatory cytokine (IL-10) was remarkably higher compared with that in the model group.
And the result of UHPLC analysis indicated that the effective parts of EMS contain berberine and atractylodin.
Conclusions.
EtOAc and CH2Cl2 are the effective parts of EMS that can improve arthritis.
In particular, berberine and atractylodin may be responsible for the antiarthritic activity of EMS.
This research provided pharmacological and chemical foundation for the application of EMS in treating rheumatoid arthritis (RA).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Wei& Zhang, Qiying& Xuan, Zihua& Liang, Juan& Yang, Dongping& Ding, Meihuizi…[et al.]. 2020. The Protective Effect of Different Polar Solvent Extracts of Er Miao San on Rats with Adjuvant Arthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156516
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Wei…[et al.]. The Protective Effect of Different Polar Solvent Extracts of Er Miao San on Rats with Adjuvant Arthritis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1156516
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Wei& Zhang, Qiying& Xuan, Zihua& Liang, Juan& Yang, Dongping& Ding, Meihuizi…[et al.]. The Protective Effect of Different Polar Solvent Extracts of Er Miao San on Rats with Adjuvant Arthritis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1156516
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156516
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر