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Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study
المؤلفون المشاركون
Märkl, B.
Schaller, Tina
Hardt, Jochen
Franz, Simon
Schenkirsch, Gerhard
Kriening, Bernadette
Hoffmann, Reinhard
Rüth, Stefan
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Aims.
The prognostic role of the proteases uPA and PAI-1, as well as tumor budding, in colon cancer, has been investigated previously.
Methods.
We provide 6-year follow-up data and results of the validation set.
The initial test set and validation set consisted of 55 colon cancers and 68 colorectal cancers, respectively.
Tissue samples were analyzed for uPA and PAI-1 using a commercially available Enzyme-Linked Immunosorbent Assay (ELISA).
Tumor budding was analyzed on cytokeratin-stained slides.
Survival analyses were performed using cut-offs that were determined previously.
Results.
uPA was not prognostic for outcome.
PAI-1 showed a trend towards reduced cancer specific survival in PAI-1 high-grade cases (68 versus 83 months; P=0.091).
The combination of high-grade PAI-1 and tumor budding was associated with significantly reduced cancer specific survival (60 versus 83 months; P=0.021).
After pooling the data from both sets, multivariate analyses revealed that the factors pN-stage, V-stage, and a combination of tumor budding and PAI-1 were independently prognostic for the association with distant metastases.
Conclusions.
A synergistic adverse effect of PAI-1 and tumor budding in uni- and multivariable analyses was found.
PAI-1 could serve as a target for anticancer therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Märkl, B.& Hardt, Jochen& Franz, Simon& Schaller, Tina& Schenkirsch, Gerhard& Kriening, Bernadette…[et al.]. 2017. Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Märkl, B.…[et al.]. Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. Gastroenterology Research and Practice No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1156539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Märkl, B.& Hardt, Jochen& Franz, Simon& Schaller, Tina& Schenkirsch, Gerhard& Kriening, Bernadette…[et al.]. Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1156539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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