Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway
المؤلفون المشاركون
Xie, Yan-Hua
Wang, Si-Wang
Liu, Yang
Li, Yao
Shi, Zhi-hui
Yang, Qian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model.
Methods.
To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days.
The histological examination, immunohistochemical analysis, and ELISA were carried out.
Furthermore, Western blotting was used to analyze the expression of Akt, MAPKs, NF-κB p65, and IκB-α in uterus.
Results.
As the results showed, infiltrations of neutrophils and lymphocytes in uterus were significantly suppressed, and IL-1β, IL-6, CXCL-1, and TNF-α were also reduced in a dose-dependent manner.
We also found that FYCWYC inhibited apoptosis induced by infection.
Furthermore, FYCWYC could block the infection-induced nuclear translocation of NF-κB.
We found that FYCWYC treatment only decreased the phosphorylation of JNK induced by infection and had no effects on Akt and P38.
Additional, the effects of SP600125, an inhibitor of phospho-JNK, were similar to the results of FYCWYC.
Conclusions.
Taken together, our results demonstrated that FYCWYC had anti-inflammatory effect in pathogen-induced PID model, and the mechanism might be through inhibiting NF-κB nuclear translocation which is mediated by JNK.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yao& Liu, Yang& Yang, Qian& Shi, Zhi-hui& Xie, Yan-Hua& Wang, Si-Wang. 2018. Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yao…[et al.]. Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yao& Liu, Yang& Yang, Qian& Shi, Zhi-hui& Xie, Yan-Hua& Wang, Si-Wang. Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر