![](/images/graphics-bg.png)
Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway
Joint Authors
Xie, Yan-Hua
Wang, Si-Wang
Liu, Yang
Li, Yao
Shi, Zhi-hui
Yang, Qian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
In this study, we aimed to illustrate the preventive effect and possible mechanisms of Feiyangchangweiyan capsule (FYCWYC) on rat pelvic inflammatory disease (PID) model.
Methods.
To construct the rat PID model, upper genital tract was infected by multipathogen, and then drugs were orally administered for 8 days.
The histological examination, immunohistochemical analysis, and ELISA were carried out.
Furthermore, Western blotting was used to analyze the expression of Akt, MAPKs, NF-κB p65, and IκB-α in uterus.
Results.
As the results showed, infiltrations of neutrophils and lymphocytes in uterus were significantly suppressed, and IL-1β, IL-6, CXCL-1, and TNF-α were also reduced in a dose-dependent manner.
We also found that FYCWYC inhibited apoptosis induced by infection.
Furthermore, FYCWYC could block the infection-induced nuclear translocation of NF-κB.
We found that FYCWYC treatment only decreased the phosphorylation of JNK induced by infection and had no effects on Akt and P38.
Additional, the effects of SP600125, an inhibitor of phospho-JNK, were similar to the results of FYCWYC.
Conclusions.
Taken together, our results demonstrated that FYCWYC had anti-inflammatory effect in pathogen-induced PID model, and the mechanism might be through inhibiting NF-κB nuclear translocation which is mediated by JNK.
American Psychological Association (APA)
Li, Yao& Liu, Yang& Yang, Qian& Shi, Zhi-hui& Xie, Yan-Hua& Wang, Si-Wang. 2018. Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156571
Modern Language Association (MLA)
Li, Yao…[et al.]. Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156571
American Medical Association (AMA)
Li, Yao& Liu, Yang& Yang, Qian& Shi, Zhi-hui& Xie, Yan-Hua& Wang, Si-Wang. Anti-Inflammatory Effect of Feiyangchangweiyan Capsule on Rat Pelvic Inflammatory Disease through JNKNF-κB Pathway. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156571