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Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis
المؤلفون المشاركون
Na, Changsu
Kim, Youg Ran
Kim, Seonjong
Bae, Kil-Joon
Jeong, Ji-Won
Choi, Chan-Hun
Won, Jeong-Yoon
Kim, Tae-Gwang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis.
ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine.
This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis.
Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group.
Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed.
Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured.
ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity.
Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels.
This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model.
These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis.
However, further studies are required to elucidate the corresponding mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bae, Kil-Joon& Jeong, Ji-Won& Choi, Chan-Hun& Won, Jeong-Yoon& Kim, Tae-Gwang& Kim, Youg Ran…[et al.]. 2018. Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156616
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bae, Kil-Joon…[et al.]. Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156616
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bae, Kil-Joon& Jeong, Ji-Won& Choi, Chan-Hun& Won, Jeong-Yoon& Kim, Tae-Gwang& Kim, Youg Ran…[et al.]. Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156616
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156616
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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