![](/images/graphics-bg.png)
Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis
Joint Authors
Na, Changsu
Kim, Youg Ran
Kim, Seonjong
Bae, Kil-Joon
Jeong, Ji-Won
Choi, Chan-Hun
Won, Jeong-Yoon
Kim, Tae-Gwang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ganghwaljetongyeum is a traditional Korean herbal medicine used to treat joint pain, limited motion, fever, and swelling; it also inhibits inflammatory processes associated with arthritis.
ChondroT, a water extract of Ganghwaljetongyeum, is a new complex herbal medicine.
This study investigated the effects of ChondroT using a rat model of monosodium iodoacetate- (MIA-) induced osteoarthritis.
Thirty-six rats were randomly divided into three ChondroT groups and a normal, control, and positive control group.
Changes in paw edema volume, histopathology, and plantar withdrawal response were analyzed.
Further, inflammatory cytokines, arachidonic acids, liver and kidney function, and hematological features were measured.
ChondroT significantly decreased paw edema by the 5th day and notably improved articular cartilage damage; it also significantly improved the plantar withdrawal response in terms of both reaction time and force intensity.
Moreover, treatment with ChondroT significantly decreased the serum levels of tumor necrosis factor alpha, interleukin-1β, interleukin-6, and prostaglandin E2 and significantly increased serum aspartate aminotransferase and alanine aminotransferase levels.
This study demonstrates that ChondroT has anti-inflammatory and analgesic effects in a MIA-induced osteoarthritis rat model.
These results support the clinical relevance of ChondroT for future use in patients with osteoarthritis.
However, further studies are required to elucidate the corresponding mechanisms.
American Psychological Association (APA)
Bae, Kil-Joon& Jeong, Ji-Won& Choi, Chan-Hun& Won, Jeong-Yoon& Kim, Tae-Gwang& Kim, Youg Ran…[et al.]. 2018. Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156616
Modern Language Association (MLA)
Bae, Kil-Joon…[et al.]. Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156616
American Medical Association (AMA)
Bae, Kil-Joon& Jeong, Ji-Won& Choi, Chan-Hun& Won, Jeong-Yoon& Kim, Tae-Gwang& Kim, Youg Ran…[et al.]. Antiosteoarthritic Effects of ChondroT in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156616
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156616