Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
المؤلفون المشاركون
Erbas, Oytun
Taskin, Banu
Erdoğan, Mümin Alper
Yiğittürk, Gürkan
Günenç, Damla
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The most severe side effect of prolonged MTX treatment is hepatotoxicity.
The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model.
Twenty-four male rats were included in the study.
Sixteen rats were given a single dose of 20 mg/kg MTX to induce liver injury.
Eight rats were given no drugs.
16 MTX-given rats were divided into two equal groups.
Group 1 subjects were given lactulose 5 g/kg/day, and group 2 subjects were given saline 1 ml/kg/day for 10 days.
The rats were then sacrificed to harvest blood and liver tissue samples in order to determine blood and tissue MDA, serum ALT, plasma TNF-α, TGF-β, and PTX3 levels.
Histological specimens were examined via light microscopy.
Exposure to MTX caused structural and functional hepatotoxicity, as evidenced by relatively worse histopathological scores and increased biochemical marker levels.
Lactulose treatment significantly reduced the liver enzyme ALT, plasma TNF-α, TGF-β, PTX3, and MDA levels and also decreased histological changes in the liver tissue with MTX-induced hepatotoxicity in the rat model.
We suggest that lactulose has anti-inflammatory and antifibrotic effects on an MTX-induced liver injury model.
These effects can be due to the impact of intestinal microbiome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taskin, Banu& Erdoğan, Mümin Alper& Yiğittürk, Gürkan& Günenç, Damla& Erbas, Oytun. 2017. Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156634
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taskin, Banu…[et al.]. Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model. Gastroenterology Research and Practice No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1156634
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taskin, Banu& Erdoğan, Mümin Alper& Yiğittürk, Gürkan& Günenç, Damla& Erbas, Oytun. Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156634
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156634
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر