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Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model
Joint Authors
Erbas, Oytun
Taskin, Banu
Erdoğan, Mümin Alper
Yiğittürk, Gürkan
Günenç, Damla
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The most severe side effect of prolonged MTX treatment is hepatotoxicity.
The aim of this study is to investigate the effect of lactulose treatment on MTX-induced hepatotoxicity in a rat model.
Twenty-four male rats were included in the study.
Sixteen rats were given a single dose of 20 mg/kg MTX to induce liver injury.
Eight rats were given no drugs.
16 MTX-given rats were divided into two equal groups.
Group 1 subjects were given lactulose 5 g/kg/day, and group 2 subjects were given saline 1 ml/kg/day for 10 days.
The rats were then sacrificed to harvest blood and liver tissue samples in order to determine blood and tissue MDA, serum ALT, plasma TNF-α, TGF-β, and PTX3 levels.
Histological specimens were examined via light microscopy.
Exposure to MTX caused structural and functional hepatotoxicity, as evidenced by relatively worse histopathological scores and increased biochemical marker levels.
Lactulose treatment significantly reduced the liver enzyme ALT, plasma TNF-α, TGF-β, PTX3, and MDA levels and also decreased histological changes in the liver tissue with MTX-induced hepatotoxicity in the rat model.
We suggest that lactulose has anti-inflammatory and antifibrotic effects on an MTX-induced liver injury model.
These effects can be due to the impact of intestinal microbiome.
American Psychological Association (APA)
Taskin, Banu& Erdoğan, Mümin Alper& Yiğittürk, Gürkan& Günenç, Damla& Erbas, Oytun. 2017. Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156634
Modern Language Association (MLA)
Taskin, Banu…[et al.]. Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model. Gastroenterology Research and Practice No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1156634
American Medical Association (AMA)
Taskin, Banu& Erdoğan, Mümin Alper& Yiğittürk, Gürkan& Günenç, Damla& Erbas, Oytun. Antifibrotic Effect of Lactulose on a Methotrexate-Induced Liver Injury Model. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1156634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156634