Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice
المؤلفون المشاركون
Celec, Peter
Bábíčková, Janka
Wagnerova, Alexandra
Liptak, Robert
Vlkova, Barbora
Gardlik, Roman
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases.
Moreover, it has been shown to interact with estrogen receptors.
In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis.
Thirty-seven C57BL/6 mice (21 female and 16 male) were divided into three groups for each sex.
The first group received pure water (CTRL).
The other two groups received 1.5% dextran sulfate sodium (DSS) to induce colitis from which one group was treated with resveratrol (DSS + RSV).
Intake of 1.5% DSS caused weight loss in all DSS groups compared to control mice.
Weight loss, stool consistency, and discomfort did not show any protective effect of resveratrol in males and showed even adverse effects in females.
In females, the activity of myeloperoxidase was lower compared to that in males.
However, colon length and spleen weight showed no sex differences, which can indicate the induction of only mild colitis in mice.
Resveratrol did not have any effect on TNF-alpha levels.
Taken together, these results for the first time propose possible diverse effects of resveratrol in DSS-induced colitis model depending on the sex of the animal.
However, this conclusion must be confirmed by further analyses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wagnerova, Alexandra& Bábíčková, Janka& Liptak, Robert& Vlkova, Barbora& Celec, Peter& Gardlik, Roman. 2017. Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1156644
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wagnerova, Alexandra…[et al.]. Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice. Gastroenterology Research and Practice No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1156644
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wagnerova, Alexandra& Bábíčková, Janka& Liptak, Robert& Vlkova, Barbora& Celec, Peter& Gardlik, Roman. Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1156644
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156644
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر