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Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice
Joint Authors
Celec, Peter
Bábíčková, Janka
Wagnerova, Alexandra
Liptak, Robert
Vlkova, Barbora
Gardlik, Roman
Source
Gastroenterology Research and Practice
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases.
Moreover, it has been shown to interact with estrogen receptors.
In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis.
Thirty-seven C57BL/6 mice (21 female and 16 male) were divided into three groups for each sex.
The first group received pure water (CTRL).
The other two groups received 1.5% dextran sulfate sodium (DSS) to induce colitis from which one group was treated with resveratrol (DSS + RSV).
Intake of 1.5% DSS caused weight loss in all DSS groups compared to control mice.
Weight loss, stool consistency, and discomfort did not show any protective effect of resveratrol in males and showed even adverse effects in females.
In females, the activity of myeloperoxidase was lower compared to that in males.
However, colon length and spleen weight showed no sex differences, which can indicate the induction of only mild colitis in mice.
Resveratrol did not have any effect on TNF-alpha levels.
Taken together, these results for the first time propose possible diverse effects of resveratrol in DSS-induced colitis model depending on the sex of the animal.
However, this conclusion must be confirmed by further analyses.
American Psychological Association (APA)
Wagnerova, Alexandra& Bábíčková, Janka& Liptak, Robert& Vlkova, Barbora& Celec, Peter& Gardlik, Roman. 2017. Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice. Gastroenterology Research and Practice،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1156644
Modern Language Association (MLA)
Wagnerova, Alexandra…[et al.]. Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice. Gastroenterology Research and Practice No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1156644
American Medical Association (AMA)
Wagnerova, Alexandra& Bábíčková, Janka& Liptak, Robert& Vlkova, Barbora& Celec, Peter& Gardlik, Roman. Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice. Gastroenterology Research and Practice. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1156644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156644