Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Chen, Guoming
Liu, Feng-bin
Jiang, Xiaotao
Jiang, Chenguang
Huang, Cihui
Jiang, Kailin
Huang, Baoyi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Objective.
To assess the effects and safety of berberine combined with triple therapy on Helicobacter pylori (H.
pylori) eradication in adults.
Methods.
PubMed, MEDLINE, EMBASE, Cochrane Library, and Chinese databases including China National Knowledge Infrastructure (CNKI), Wanfang data, Chinese Technology Journal Full-text Database (VIP), and China biomedical literature database (CBM) were searched to obtain the eligible studies published up to October 10, 2017.
The primary outcome was eradication rate of H.
pylori.
The secondary outcome was incidence of adverse effects.
Data analysis was conducted by RevMan5.2 and Stata V.9.0 software.
Trial sequential analysis (TSA) was performed to assess the risk of random error and the validity of conclusion with TSA program version 0.9 beta.
Results.
The meta-analysis results indicated berberine combined with triple therapy could improve the eradication rates of H.
pylori (urea breath test subgroup: RR=1.18, 95%CI=(1.12,1.24), P<0.00001, biopsy subgroup: RR=1.23, 95%CI=(1.13,1.34), P<0.00001) and reduce the total occurrence of adverse effects (OR=0.59, 95%CI(0.46, 0.75), P<0.0001) when compared with only using triple therapy.
Besides, the incidence of nausea (OR=0.59, 95%CI(0.41, 0.86), P<0.05) and diarrhea (OR=0.41, 95%CI(0.24, 0.71) was remarkably lower in experimental group while that of abdominal distention (OR=0.64, 95%CI(0.40,1.04), P>0.05) and vomiting (OR=0.65, 95%CI(0.37, 1.15), P>0.05) had no significant change.
TSA of H.
pylori eradication rates and adverse effects incidence illustrated that the cumulative value of Z-curve went across the conventional boundary value, trial sequential monitoring boundary for benefit, and required information size, suggesting the results were stable.
Conclusion.
Evidence from meta-analysis suggested that berberine combined with triple therapy can be an option for increasing H.
pylori eradication rates and reducing overall therapy-related adverse effects incidence, particularly nausea and diarrhea, whereas more randomized controlled trials designed according to CONSORT statement are demanded to support the efficacy in further studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Xiaotao& Jiang, Chenguang& Huang, Cihui& Chen, Guoming& Jiang, Kailin& Huang, Baoyi…[et al.]. 2018. Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Xiaotao…[et al.]. Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1156714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Xiaotao& Jiang, Chenguang& Huang, Cihui& Chen, Guoming& Jiang, Kailin& Huang, Baoyi…[et al.]. Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر