Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Chen, Guoming
Liu, Feng-bin
Jiang, Xiaotao
Jiang, Chenguang
Huang, Cihui
Jiang, Kailin
Huang, Baoyi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objective.
To assess the effects and safety of berberine combined with triple therapy on Helicobacter pylori (H.
pylori) eradication in adults.
Methods.
PubMed, MEDLINE, EMBASE, Cochrane Library, and Chinese databases including China National Knowledge Infrastructure (CNKI), Wanfang data, Chinese Technology Journal Full-text Database (VIP), and China biomedical literature database (CBM) were searched to obtain the eligible studies published up to October 10, 2017.
The primary outcome was eradication rate of H.
pylori.
The secondary outcome was incidence of adverse effects.
Data analysis was conducted by RevMan5.2 and Stata V.9.0 software.
Trial sequential analysis (TSA) was performed to assess the risk of random error and the validity of conclusion with TSA program version 0.9 beta.
Results.
The meta-analysis results indicated berberine combined with triple therapy could improve the eradication rates of H.
pylori (urea breath test subgroup: RR=1.18, 95%CI=(1.12,1.24), P<0.00001, biopsy subgroup: RR=1.23, 95%CI=(1.13,1.34), P<0.00001) and reduce the total occurrence of adverse effects (OR=0.59, 95%CI(0.46, 0.75), P<0.0001) when compared with only using triple therapy.
Besides, the incidence of nausea (OR=0.59, 95%CI(0.41, 0.86), P<0.05) and diarrhea (OR=0.41, 95%CI(0.24, 0.71) was remarkably lower in experimental group while that of abdominal distention (OR=0.64, 95%CI(0.40,1.04), P>0.05) and vomiting (OR=0.65, 95%CI(0.37, 1.15), P>0.05) had no significant change.
TSA of H.
pylori eradication rates and adverse effects incidence illustrated that the cumulative value of Z-curve went across the conventional boundary value, trial sequential monitoring boundary for benefit, and required information size, suggesting the results were stable.
Conclusion.
Evidence from meta-analysis suggested that berberine combined with triple therapy can be an option for increasing H.
pylori eradication rates and reducing overall therapy-related adverse effects incidence, particularly nausea and diarrhea, whereas more randomized controlled trials designed according to CONSORT statement are demanded to support the efficacy in further studies.
American Psychological Association (APA)
Jiang, Xiaotao& Jiang, Chenguang& Huang, Cihui& Chen, Guoming& Jiang, Kailin& Huang, Baoyi…[et al.]. 2018. Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156714
Modern Language Association (MLA)
Jiang, Xiaotao…[et al.]. Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1156714
American Medical Association (AMA)
Jiang, Xiaotao& Jiang, Chenguang& Huang, Cihui& Chen, Guoming& Jiang, Kailin& Huang, Baoyi…[et al.]. Berberine Combined with Triple Therapy versus Triple Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1156714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156714