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Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats
المؤلفون المشاركون
Liao, Jiunn-Wang
Wen, Chi-Luan
Yang, Li-Chan
Lin, Wen-Chuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Dendrobium Taiseed Tosnobile is a new species of herba dendrobii (Shi-Hu) that was developed by crossbreeding D.
tosaense and D.
nobile.
Its pharmacological activity and active component have been reported, but its subchronic toxicity and genetic safety have not yet been investigated.
This study assessed the 90-day oral toxicity and genetic safety of the aqueous extracts of D.
Taiseed Tosnobile (DTTE) in male and female Sprague-Dawley (SD) rats.
Eighty rats were divided into four groups, each consisting of ten male and ten female rats.
DTTE was given orally to rats at 800, 1600, or 2400 mg/kg for 90 consecutive days, and distilled water was used for the control group.
Genotoxicity studies were performed using a bacterial reverse mutation assay and in vivo mammalian cell micronucleus test in ICR mice and analyzed using flow cytometry.
Throughout the study period, no abnormal changes were observed in clinical signs and body weight or on ophthalmological examinations.
Additionally, no significant differences were found in urinalysis, hematology, and serum biochemistry parameters between the treatment and control groups.
Necropsy and histopathological examination indicated no treatment-related changes.
Based on results, the no-observed-adverse-effect level of DTTE is greater than 2400 mg/kg in SD rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Li-Chan& Liao, Jiunn-Wang& Wen, Chi-Luan& Lin, Wen-Chuan. 2018. Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Li-Chan…[et al.]. Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Li-Chan& Liao, Jiunn-Wang& Wen, Chi-Luan& Lin, Wen-Chuan. Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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