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Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats
Joint Authors
Liao, Jiunn-Wang
Wen, Chi-Luan
Yang, Li-Chan
Lin, Wen-Chuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Dendrobium Taiseed Tosnobile is a new species of herba dendrobii (Shi-Hu) that was developed by crossbreeding D.
tosaense and D.
nobile.
Its pharmacological activity and active component have been reported, but its subchronic toxicity and genetic safety have not yet been investigated.
This study assessed the 90-day oral toxicity and genetic safety of the aqueous extracts of D.
Taiseed Tosnobile (DTTE) in male and female Sprague-Dawley (SD) rats.
Eighty rats were divided into four groups, each consisting of ten male and ten female rats.
DTTE was given orally to rats at 800, 1600, or 2400 mg/kg for 90 consecutive days, and distilled water was used for the control group.
Genotoxicity studies were performed using a bacterial reverse mutation assay and in vivo mammalian cell micronucleus test in ICR mice and analyzed using flow cytometry.
Throughout the study period, no abnormal changes were observed in clinical signs and body weight or on ophthalmological examinations.
Additionally, no significant differences were found in urinalysis, hematology, and serum biochemistry parameters between the treatment and control groups.
Necropsy and histopathological examination indicated no treatment-related changes.
Based on results, the no-observed-adverse-effect level of DTTE is greater than 2400 mg/kg in SD rats.
American Psychological Association (APA)
Yang, Li-Chan& Liao, Jiunn-Wang& Wen, Chi-Luan& Lin, Wen-Chuan. 2018. Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156772
Modern Language Association (MLA)
Yang, Li-Chan…[et al.]. Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1156772
American Medical Association (AMA)
Yang, Li-Chan& Liao, Jiunn-Wang& Wen, Chi-Luan& Lin, Wen-Chuan. Subchronic and Genetic Safety Assessment of a New Medicinal Dendrobium Species: Dendrobium Taiseed Tosnobile in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1156772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156772