6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury

الملخص EN

6-Gingerol (6-G) is known to alleviate myocardial ischemia/reperfusion injury.

However, the underlying molecular mechanisms of 6-G myocardial protection are not known.

In this study, the protective effect of 6-G on ischemia/reperfusion (I/R) damage and whether such a mechanism was related to apoptosis inhibition and activation of phosphoinositide 3-kinases (PI3K)/serine/threonine kinase (Akt) signaling pathway were investigated.

Rats were subjected to I/R in the presence or absence of 6-G and the changes of cardiac function, infarct size and histopathological changes, and the levels of cardiac troponin T, creatine kinase-MB, and myocardial apoptosis were examined.

The expression of caspase-3, PI3K, p-Akt, and Akt was also determined.

We found that 6-G (6 mg/kg) pretreatment significantly improved heart function and ameliorated infarct size and histopathological changes and cardiac troponin T and creatine kinase-MB levels induced by I/R.

Moreover, pretreatment with 6-G significantly inhibited myocardial apoptosis and caspase-3 activation induced by I/R.

6-G also upregulated expression of PI3K, p-Akt, and Akt in myocardial tissues.

Taken together, these findings suggest that 6-G inhibits apoptosis and activates PI3K/Akt signaling in response to myocardial I/R injury as a possible mechanism to attenuate I/R-induced injury in heart.

These results might be important for developing novel strategies for preventing myocardial I/R injury.