6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury
المؤلفون المشاركون
Zhong, Guo-qiang
Wu, Qi
Xu, Tongtong
Lv, Xiangwei
Zhou, Yao
Huang, Guidong
Xu, Yongnan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
6-Gingerol (6-G) is known to alleviate myocardial ischemia/reperfusion injury.
However, the underlying molecular mechanisms of 6-G myocardial protection are not known.
In this study, the protective effect of 6-G on ischemia/reperfusion (I/R) damage and whether such a mechanism was related to apoptosis inhibition and activation of phosphoinositide 3-kinases (PI3K)/serine/threonine kinase (Akt) signaling pathway were investigated.
Rats were subjected to I/R in the presence or absence of 6-G and the changes of cardiac function, infarct size and histopathological changes, and the levels of cardiac troponin T, creatine kinase-MB, and myocardial apoptosis were examined.
The expression of caspase-3, PI3K, p-Akt, and Akt was also determined.
We found that 6-G (6 mg/kg) pretreatment significantly improved heart function and ameliorated infarct size and histopathological changes and cardiac troponin T and creatine kinase-MB levels induced by I/R.
Moreover, pretreatment with 6-G significantly inhibited myocardial apoptosis and caspase-3 activation induced by I/R.
6-G also upregulated expression of PI3K, p-Akt, and Akt in myocardial tissues.
Taken together, these findings suggest that 6-G inhibits apoptosis and activates PI3K/Akt signaling in response to myocardial I/R injury as a possible mechanism to attenuate I/R-induced injury in heart.
These results might be important for developing novel strategies for preventing myocardial I/R injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lv, Xiangwei& Xu, Tongtong& Wu, Qi& Zhou, Yao& Huang, Guidong& Xu, Yongnan…[et al.]. 2018. 6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156786
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lv, Xiangwei…[et al.]. 6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156786
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lv, Xiangwei& Xu, Tongtong& Wu, Qi& Zhou, Yao& Huang, Guidong& Xu, Yongnan…[et al.]. 6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156786
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156786
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر