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6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury
Joint Authors
Zhong, Guo-qiang
Wu, Qi
Xu, Tongtong
Lv, Xiangwei
Zhou, Yao
Huang, Guidong
Xu, Yongnan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
6-Gingerol (6-G) is known to alleviate myocardial ischemia/reperfusion injury.
However, the underlying molecular mechanisms of 6-G myocardial protection are not known.
In this study, the protective effect of 6-G on ischemia/reperfusion (I/R) damage and whether such a mechanism was related to apoptosis inhibition and activation of phosphoinositide 3-kinases (PI3K)/serine/threonine kinase (Akt) signaling pathway were investigated.
Rats were subjected to I/R in the presence or absence of 6-G and the changes of cardiac function, infarct size and histopathological changes, and the levels of cardiac troponin T, creatine kinase-MB, and myocardial apoptosis were examined.
The expression of caspase-3, PI3K, p-Akt, and Akt was also determined.
We found that 6-G (6 mg/kg) pretreatment significantly improved heart function and ameliorated infarct size and histopathological changes and cardiac troponin T and creatine kinase-MB levels induced by I/R.
Moreover, pretreatment with 6-G significantly inhibited myocardial apoptosis and caspase-3 activation induced by I/R.
6-G also upregulated expression of PI3K, p-Akt, and Akt in myocardial tissues.
Taken together, these findings suggest that 6-G inhibits apoptosis and activates PI3K/Akt signaling in response to myocardial I/R injury as a possible mechanism to attenuate I/R-induced injury in heart.
These results might be important for developing novel strategies for preventing myocardial I/R injury.
American Psychological Association (APA)
Lv, Xiangwei& Xu, Tongtong& Wu, Qi& Zhou, Yao& Huang, Guidong& Xu, Yongnan…[et al.]. 2018. 6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156786
Modern Language Association (MLA)
Lv, Xiangwei…[et al.]. 6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1156786
American Medical Association (AMA)
Lv, Xiangwei& Xu, Tongtong& Wu, Qi& Zhou, Yao& Huang, Guidong& Xu, Yongnan…[et al.]. 6-Gingerol Activates PI3KAkt and Inhibits Apoptosis to Attenuate Myocardial IschemiaReperfusion Injury. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1156786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156786