Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke
المؤلفون المشاركون
Chen, Zhenxing
Yan, Qiangqiang
Zhang, Zhongmin
Lan, Taijin
Liu, Peng
Han, Siyin
Lin, Yong
Lin, Jiang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-18
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death around the world.
The present study is designed to investigate whether hydrolyzed seawater pearl tablet (HSPT) has immunoregulatory effects on the Th1/Th2 functionality in cigarette smoke-induced COPD model mice.
The determination of the amino acid composition of HSPT was carried out by high-performance liquid chromatography (HPLC) with precolumn phenylisothiocyanate (PITC) derivatization.
COPD model mice were constructed by cigarette smoking (CS) treatment and HSPT was administered.
HSPT inhibited the infiltration of inflammation in the airway of the lung, reduced influx of eosinophils (EOSs), lymphocytes (LYMs), neutrophils (NEUs), and macrophages (MACs) in the bronchoalveolar lavage fluid (BALF), decreased the levels of IFN-γ, IL-2, IL-4, and IL-10 in the serum and lung, and decreased the expression of aforementioned cytokines in the spleen and lung in CS-treated mice.
Besides, HSPT also had the ability to reduce the amount of CD3+CD4+ T cells and modulate the Th1/Th2 balance.
Taken together, this study supports the consensus that CS is a critical factor to induce and aggravate COPD.
HSPT could regulate the balance of Th1/Th2 in CS-induced COPD model mice, indicating its effects on inhibiting the development of COPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Zhenxing& Yan, Qiangqiang& Zhang, Zhongmin& Lan, Taijin& Liu, Peng& Han, Siyin…[et al.]. 2020. Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1156793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Zhenxing…[et al.]. Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1156793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Zhenxing& Yan, Qiangqiang& Zhang, Zhongmin& Lan, Taijin& Liu, Peng& Han, Siyin…[et al.]. Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1156793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر