Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke
Joint Authors
Chen, Zhenxing
Yan, Qiangqiang
Zhang, Zhongmin
Lan, Taijin
Liu, Peng
Han, Siyin
Lin, Yong
Lin, Jiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-18
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death around the world.
The present study is designed to investigate whether hydrolyzed seawater pearl tablet (HSPT) has immunoregulatory effects on the Th1/Th2 functionality in cigarette smoke-induced COPD model mice.
The determination of the amino acid composition of HSPT was carried out by high-performance liquid chromatography (HPLC) with precolumn phenylisothiocyanate (PITC) derivatization.
COPD model mice were constructed by cigarette smoking (CS) treatment and HSPT was administered.
HSPT inhibited the infiltration of inflammation in the airway of the lung, reduced influx of eosinophils (EOSs), lymphocytes (LYMs), neutrophils (NEUs), and macrophages (MACs) in the bronchoalveolar lavage fluid (BALF), decreased the levels of IFN-γ, IL-2, IL-4, and IL-10 in the serum and lung, and decreased the expression of aforementioned cytokines in the spleen and lung in CS-treated mice.
Besides, HSPT also had the ability to reduce the amount of CD3+CD4+ T cells and modulate the Th1/Th2 balance.
Taken together, this study supports the consensus that CS is a critical factor to induce and aggravate COPD.
HSPT could regulate the balance of Th1/Th2 in CS-induced COPD model mice, indicating its effects on inhibiting the development of COPD.
American Psychological Association (APA)
Chen, Zhenxing& Yan, Qiangqiang& Zhang, Zhongmin& Lan, Taijin& Liu, Peng& Han, Siyin…[et al.]. 2020. Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1156793
Modern Language Association (MLA)
Chen, Zhenxing…[et al.]. Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1156793
American Medical Association (AMA)
Chen, Zhenxing& Yan, Qiangqiang& Zhang, Zhongmin& Lan, Taijin& Liu, Peng& Han, Siyin…[et al.]. Immunomodulatory Effects of Hydrolyzed Seawater Pearl Tablet (HSPT) on Th1Th2 Functionality in a Mice Model of Chronic Obstructive Pulmonary Disease (COPD) Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1156793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156793