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Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats
المؤلفون المشاركون
Ding, Shan-Shan
Li, Candong
Asakawa, Tetsuya
Liang, Wenna
Li, Xihai
Li, Guanhui
Hu, Liu
Kang, Jie
Shen, Jianying
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China.
However, its molecular mechanisms remain unclear.
The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP.
We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model.
We then investigated the expression of biomarkers related to the Sirt1/Foxo axis.
We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression.
The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration.
The antiosteoporotic effect of EZP was confirmed.
We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration.
And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration.
These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Wenna& Li, Xihai& Li, Guanhui& Hu, Liu& Ding, Shan-Shan& Kang, Jie…[et al.]. 2018. Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Wenna…[et al.]. Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Wenna& Li, Xihai& Li, Guanhui& Hu, Liu& Ding, Shan-Shan& Kang, Jie…[et al.]. Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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