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Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats
Joint Authors
Ding, Shan-Shan
Li, Candong
Asakawa, Tetsuya
Liang, Wenna
Li, Xihai
Li, Guanhui
Hu, Liu
Kang, Jie
Shen, Jianying
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Erzhi pill (EZP), a traditional Chinese herbal formula, has been widely used to treat postmenopausal osteoporosis (PMOP) in China.
However, its molecular mechanisms remain unclear.
The aim of the present study is to investigate the antiosteoporotic effect of EZP on an ovariectomized rat model of PMOP.
We performed the biomarkers of bone metabolism disorder, bone morphology, bone mineral density (BMD), and bone biomechanics to confirm the successful establishment of the PMOP model.
We then investigated the expression of biomarkers related to the Sirt1/Foxo axis.
We also examined microRNA-132 (miR-132), a regulator in the Sirtuin1 (Sirt1) expression.
The bone metabolism disorder, bone morphology, BMD, and bone biomechanics in ovariectomized rats were improved by EZP administration.
The antiosteoporotic effect of EZP was confirmed.
We also found that the expressions of Sirt1, Runx2, Foxo1, and Foxo3a were downregulated in ovariectomized rats, while being then upregulated by EZP administration.
And the expression of PPAR-γ and miR-132 was upregulated in ovariectomized rats and then downregulated by EZP administration.
These results provided evidence that Sirt1/Foxo axis related mechanism may play a crucial role in the therapeutic effects of EZP, indicating that Sirt1/Foxo axis can be considered as a potential therapeutic target for PMOP in the future.
American Psychological Association (APA)
Liang, Wenna& Li, Xihai& Li, Guanhui& Hu, Liu& Ding, Shan-Shan& Kang, Jie…[et al.]. 2018. Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156834
Modern Language Association (MLA)
Liang, Wenna…[et al.]. Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1156834
American Medical Association (AMA)
Liang, Wenna& Li, Xihai& Li, Guanhui& Hu, Liu& Ding, Shan-Shan& Kang, Jie…[et al.]. Sirt1Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1156834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156834