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In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei
المؤلفون المشاركون
Huluka, Solomon Assefa
Nureye, Dejen
Nedi, Teshome
Engidawork, Ephrem
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Evolution of antimalarial drug resistance makes the development of new drugs a necessity.
Important source in search of such drugs is medicinal plants.
Gardenia ternifolia plant is used in Ethiopian traditional medicine for the treatment of malaria and is endowed with in vitro antimalarial activity.
Herein, the in vivo antimalarial activity of the plant was investigated.
Methods.
Acute toxicity was carried out using a standard procedure.
A 4-day suppressive test was employed to evaluate the antimalarial effect of methanolic crude extract and solvent fractions of the plant.
The curative and prophylactic effect of crude extract was further tested by Ranes’s test and residual infection procedure, respectively, using Plasmodium berghei (ANKA strain) in Swiss albino mice.
Results.
The chemosuppressive effect exerted by the crude extract and fractions ranged between 30-59% and 14-51%, respectively.
Curative and prophylactic effects of the crude extract were in the range of 36-63% and 24-37%, respectively.
All dose levels of the crude extract prevented loss of weight, reduction in temperature, and anemia on early and established infection.
Butanol and chloroform fractions also did reverse reduction in temperature, body weight, and packed cell volume.
Conclusions.
The results indicated that the plant has a promising antiplasmodial activity and it could be considered as a potential source to develop new antimalarial agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nureye, Dejen& Huluka, Solomon Assefa& Nedi, Teshome& Engidawork, Ephrem. 2018. In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156844
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nureye, Dejen…[et al.]. In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156844
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nureye, Dejen& Huluka, Solomon Assefa& Nedi, Teshome& Engidawork, Ephrem. In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156844
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156844
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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