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In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei
Joint Authors
Huluka, Solomon Assefa
Nureye, Dejen
Nedi, Teshome
Engidawork, Ephrem
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Evolution of antimalarial drug resistance makes the development of new drugs a necessity.
Important source in search of such drugs is medicinal plants.
Gardenia ternifolia plant is used in Ethiopian traditional medicine for the treatment of malaria and is endowed with in vitro antimalarial activity.
Herein, the in vivo antimalarial activity of the plant was investigated.
Methods.
Acute toxicity was carried out using a standard procedure.
A 4-day suppressive test was employed to evaluate the antimalarial effect of methanolic crude extract and solvent fractions of the plant.
The curative and prophylactic effect of crude extract was further tested by Ranes’s test and residual infection procedure, respectively, using Plasmodium berghei (ANKA strain) in Swiss albino mice.
Results.
The chemosuppressive effect exerted by the crude extract and fractions ranged between 30-59% and 14-51%, respectively.
Curative and prophylactic effects of the crude extract were in the range of 36-63% and 24-37%, respectively.
All dose levels of the crude extract prevented loss of weight, reduction in temperature, and anemia on early and established infection.
Butanol and chloroform fractions also did reverse reduction in temperature, body weight, and packed cell volume.
Conclusions.
The results indicated that the plant has a promising antiplasmodial activity and it could be considered as a potential source to develop new antimalarial agents.
American Psychological Association (APA)
Nureye, Dejen& Huluka, Solomon Assefa& Nedi, Teshome& Engidawork, Ephrem. 2018. In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156844
Modern Language Association (MLA)
Nureye, Dejen…[et al.]. In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1156844
American Medical Association (AMA)
Nureye, Dejen& Huluka, Solomon Assefa& Nedi, Teshome& Engidawork, Ephrem. In Vivo Antimalarial Activity of the 80% Methanolic Root Bark Extract and Solvent Fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1156844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156844