Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats
المؤلفون المشاركون
Ismail, Morouj
Hasan, Hiba
El-Orfali, Youmna
Ismail, Hanan
Khawaja, Ghada
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Rheumatoid arthritis (RA) is a painful chronic autoimmune disease affecting the joints.
Its first-line therapy, Methotrexate (MTX), although effective in ameliorating the progress of the disease, induces hepatotoxicity over long-term usage.
Thus, seeking natural compounds with fewer side effects could be an alternative therapeutic approach.
This study aimed to investigate the anti-inflammatory, antiarthritic, and antioxidative effects of synthetic trans-Δ9-tetrahydrocannabinol (Δ9-THC) dissolved in sesame oil (Dronabinol) against MTX in adjuvant-induced arthritis (AIA) rat model.
Daily oral administration of Δ9-THC/sesame oil, over a period of 21 days, was well tolerated in arthritic rats with no particular psychoactive side effects.
It markedly attenuated the severity of clinical manifestations, recovered the histopathological changes in tibiotarsal joints, and repressed the splenomegaly in arthritic rats.
Δ9-THC/sesame oil therapy showed similar effects to MTX in neutralizing the inflammatory process of AIA, through attenuating erythrocyte sedimentation rate (ESR) scores and proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), and interleukin-6 (IL-6) levels, to normal values.
As opposed to MTX, this natural combination markedly protected the liver of arthritic rats and downregulated the induced oxidative stress by increasing the antioxidant defense system such as activities of catalase and superoxide dismutase (SOD) and levels of glutathione (GSH).
These results suggest promising effects for the clinical use of Δ9-THC/sesame oil therapy in alleviating arthritic clinical signs as well as arthritis-induced liver injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ismail, Morouj& Hasan, Hiba& El-Orfali, Youmna& Ismail, Hanan& Khawaja, Ghada. 2018. Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ismail, Morouj…[et al.]. Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ismail, Morouj& Hasan, Hiba& El-Orfali, Youmna& Ismail, Hanan& Khawaja, Ghada. Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر