Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats
Joint Authors
Ismail, Morouj
Hasan, Hiba
El-Orfali, Youmna
Ismail, Hanan
Khawaja, Ghada
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a painful chronic autoimmune disease affecting the joints.
Its first-line therapy, Methotrexate (MTX), although effective in ameliorating the progress of the disease, induces hepatotoxicity over long-term usage.
Thus, seeking natural compounds with fewer side effects could be an alternative therapeutic approach.
This study aimed to investigate the anti-inflammatory, antiarthritic, and antioxidative effects of synthetic trans-Δ9-tetrahydrocannabinol (Δ9-THC) dissolved in sesame oil (Dronabinol) against MTX in adjuvant-induced arthritis (AIA) rat model.
Daily oral administration of Δ9-THC/sesame oil, over a period of 21 days, was well tolerated in arthritic rats with no particular psychoactive side effects.
It markedly attenuated the severity of clinical manifestations, recovered the histopathological changes in tibiotarsal joints, and repressed the splenomegaly in arthritic rats.
Δ9-THC/sesame oil therapy showed similar effects to MTX in neutralizing the inflammatory process of AIA, through attenuating erythrocyte sedimentation rate (ESR) scores and proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), and interleukin-6 (IL-6) levels, to normal values.
As opposed to MTX, this natural combination markedly protected the liver of arthritic rats and downregulated the induced oxidative stress by increasing the antioxidant defense system such as activities of catalase and superoxide dismutase (SOD) and levels of glutathione (GSH).
These results suggest promising effects for the clinical use of Δ9-THC/sesame oil therapy in alleviating arthritic clinical signs as well as arthritis-induced liver injury.
American Psychological Association (APA)
Ismail, Morouj& Hasan, Hiba& El-Orfali, Youmna& Ismail, Hanan& Khawaja, Ghada. 2018. Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156877
Modern Language Association (MLA)
Ismail, Morouj…[et al.]. Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1156877
American Medical Association (AMA)
Ismail, Morouj& Hasan, Hiba& El-Orfali, Youmna& Ismail, Hanan& Khawaja, Ghada. Anti-Inflammatory, Antioxidative, and Hepatoprotective Effects of Trans Δ9-TetrahydrocannabinolSesame Oil on Adjuvant-Induced Arthritis in Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1156877
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156877