Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line
المؤلفون المشاركون
Choi, Yu-Jeong
Kim, Myeong-Sun
Lee, Kangwook
Ku, Jin Mo
Mok, Kyungyul
Kim, Doori
Cheon, Chunhoo
Ko, Seong-Gyu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Pancreatic cancer has a poor prognosis with a five-year survival rate of less than 10%.
Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity.
Therefore, the development of effective therapeutic strategies and novel drugs against pancreatic cancer is an urgent need.
Cucurbitacin D (CuD), a plant steroid derived from Trichosanthes kirilowii, is an anticancer agent effective against various cancer cell lines.
However, the anticancer activity and molecular mechanism of CuD in pancreatic cancer remain unknown.
Therefore, we aimed to investigate the anticancer activity and molecular mechanism of CuD in the human pancreatic cancer cell line, Capan-1.
CuD induced cell cycle arrest at the G2/M phase, apoptosis, and reactive oxygen species generation in Capan-1 cell line.
In addition, CuD induced the activation of the p38 MAPK signaling pathway that regulates apoptosis, which was also inhibited by N-acetyl-L-cysteine and the p38 inhibitor SB203580.
These data suggest that CuD induces cell cycle arrest and apoptosis via the ROS/p38 pathway in Capan-1 pancreatic cancer cell line; hence, CuD is a promising candidate that should be explored further for its effectiveness as an anticancer agent against pancreatic cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Myeong-Sun& Lee, Kangwook& Ku, Jin Mo& Choi, Yu-Jeong& Mok, Kyungyul& Kim, Doori…[et al.]. 2020. Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Myeong-Sun…[et al.]. Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Myeong-Sun& Lee, Kangwook& Ku, Jin Mo& Choi, Yu-Jeong& Mok, Kyungyul& Kim, Doori…[et al.]. Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1156984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر