Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line
Joint Authors
Choi, Yu-Jeong
Kim, Myeong-Sun
Lee, Kangwook
Ku, Jin Mo
Mok, Kyungyul
Kim, Doori
Cheon, Chunhoo
Ko, Seong-Gyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pancreatic cancer has a poor prognosis with a five-year survival rate of less than 10%.
Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity.
Therefore, the development of effective therapeutic strategies and novel drugs against pancreatic cancer is an urgent need.
Cucurbitacin D (CuD), a plant steroid derived from Trichosanthes kirilowii, is an anticancer agent effective against various cancer cell lines.
However, the anticancer activity and molecular mechanism of CuD in pancreatic cancer remain unknown.
Therefore, we aimed to investigate the anticancer activity and molecular mechanism of CuD in the human pancreatic cancer cell line, Capan-1.
CuD induced cell cycle arrest at the G2/M phase, apoptosis, and reactive oxygen species generation in Capan-1 cell line.
In addition, CuD induced the activation of the p38 MAPK signaling pathway that regulates apoptosis, which was also inhibited by N-acetyl-L-cysteine and the p38 inhibitor SB203580.
These data suggest that CuD induces cell cycle arrest and apoptosis via the ROS/p38 pathway in Capan-1 pancreatic cancer cell line; hence, CuD is a promising candidate that should be explored further for its effectiveness as an anticancer agent against pancreatic cancer.
American Psychological Association (APA)
Kim, Myeong-Sun& Lee, Kangwook& Ku, Jin Mo& Choi, Yu-Jeong& Mok, Kyungyul& Kim, Doori…[et al.]. 2020. Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156984
Modern Language Association (MLA)
Kim, Myeong-Sun…[et al.]. Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1156984
American Medical Association (AMA)
Kim, Myeong-Sun& Lee, Kangwook& Ku, Jin Mo& Choi, Yu-Jeong& Mok, Kyungyul& Kim, Doori…[et al.]. Cucurbitacin D Induces G2M Phase Arrest and Apoptosis via the ROSp38 Pathway in Capan-1 Pancreatic Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1156984
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1156984