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Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats
المؤلفون المشاركون
Sun, Guangren
Yu, Chunyan
Yuan, Rui
Yu, Zepeng
Sun, Jinghui
Gao, Jiaqi
Wang, Chunmei
Li, He
Chen, Jianguang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hyperlipidemia and its associated obesity, hepatic steatosis, and NAFLD are worldwide problems.
However, there is no ideal pharmacological treatment for these.
Therefore, the complementary therapies that are both natural and safe have been focused.
Healthy foods, such as fruit vinegar, may be one of the best choices.
In this study, we made a special medicinal fruit vinegar, Schisandra fruit vinegar (SV), and examined its lipid-lowering effects and the underlying mechanisms in a high-fat diet rat model.
The results showed that SV significantly reduced the body weight, liver weight, liver index, the serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), free fatty acid (FFA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA), increased the content of high-density lipoprotein cholesterol (HDL-C) and the activity of superoxide dismutase (SOD), upregulated the expressions of peroxisome proliferative activated receptor (PPAR-α), peroxisomal acyl-coenzyme A oxidase 1 (ACOX1), and carnitine palmitoyltransferase 1 (CPT1) proteins, increased the contents of key component of antioxidant defense NF-E2-related factor 2 (NRF2) and its downstream heme oxygenase-1 (HO-1) protein, and downregulated the expression of Kelch-like ECH-associated protein 1 (KEAP1).
These results suggest that SV has weight loss and lipid-lowering effects in HFD rats, which may be related to its upregulation of the expressions of β-oxidation -elated PPAR-α, CPT1, and ACOX1 and the regulation of the expressions of antioxidant pathway-related KEAP1-NRF2-HO-1.
Therefore, all these data provide an experimental basis for the development of SV as a functional beverage which is safe, effective, convenient, and inexpensive.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yuan, Rui& Sun, Guangren& Gao, Jiaqi& Yu, Zepeng& Yu, Chunyan& Wang, Chunmei…[et al.]. 2020. Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yuan, Rui…[et al.]. Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yuan, Rui& Sun, Guangren& Gao, Jiaqi& Yu, Zepeng& Yu, Chunyan& Wang, Chunmei…[et al.]. Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157163
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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