Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats
Joint Authors
Sun, Guangren
Yu, Chunyan
Yuan, Rui
Yu, Zepeng
Sun, Jinghui
Gao, Jiaqi
Wang, Chunmei
Li, He
Chen, Jianguang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hyperlipidemia and its associated obesity, hepatic steatosis, and NAFLD are worldwide problems.
However, there is no ideal pharmacological treatment for these.
Therefore, the complementary therapies that are both natural and safe have been focused.
Healthy foods, such as fruit vinegar, may be one of the best choices.
In this study, we made a special medicinal fruit vinegar, Schisandra fruit vinegar (SV), and examined its lipid-lowering effects and the underlying mechanisms in a high-fat diet rat model.
The results showed that SV significantly reduced the body weight, liver weight, liver index, the serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), free fatty acid (FFA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA), increased the content of high-density lipoprotein cholesterol (HDL-C) and the activity of superoxide dismutase (SOD), upregulated the expressions of peroxisome proliferative activated receptor (PPAR-α), peroxisomal acyl-coenzyme A oxidase 1 (ACOX1), and carnitine palmitoyltransferase 1 (CPT1) proteins, increased the contents of key component of antioxidant defense NF-E2-related factor 2 (NRF2) and its downstream heme oxygenase-1 (HO-1) protein, and downregulated the expression of Kelch-like ECH-associated protein 1 (KEAP1).
These results suggest that SV has weight loss and lipid-lowering effects in HFD rats, which may be related to its upregulation of the expressions of β-oxidation -elated PPAR-α, CPT1, and ACOX1 and the regulation of the expressions of antioxidant pathway-related KEAP1-NRF2-HO-1.
Therefore, all these data provide an experimental basis for the development of SV as a functional beverage which is safe, effective, convenient, and inexpensive.
American Psychological Association (APA)
Yuan, Rui& Sun, Guangren& Gao, Jiaqi& Yu, Zepeng& Yu, Chunyan& Wang, Chunmei…[et al.]. 2020. Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157163
Modern Language Association (MLA)
Yuan, Rui…[et al.]. Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157163
American Medical Association (AMA)
Yuan, Rui& Sun, Guangren& Gao, Jiaqi& Yu, Zepeng& Yu, Chunyan& Wang, Chunmei…[et al.]. Schisandra Fruit Vinegar Lowers Lipid Profile in High-Fat Diet Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157163