Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption
المؤلفون المشاركون
Wang, Ye-fang
Fei, Yu-xiang
Zhao, Bo
Yin, Qi-yang
Zhu, Jian-ping
Ren, Guang-hui
Wang, Bo-wen
Fang, Wei-rong
Li, Yun-man
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-17
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
This research was designed to explore the effect of Ma Xing Shi Gan decoction (MXD) in alleviating particulate matter less than 2.5 μm in diameter (PM2.5) induced lung injury from the perspective of epithelial barrier protection and inhibition of epithelial-to-mesenchymal transition (EMT).
Rats were exposed to PM2.5 to establish a lung injury model in vivo, and a PM2.5-stimulated primary cultured type II alveolar epithelial cell model was introduced in vitro.
Our results indicated that MXD alleviated the weight loss and pathologic changes and improved the epithelial barrier dysfunction.
MXD also significantly inhibited the TGF-β/Smad3 pathway, increased the level of ZO-1 and claudin-5, and reversed the EMT process.
Notably, the protection of MXD was abolished by TGF-β in vitro.
Our results indicated that MXD has a protection against PM2.5-induced lung injury.
The proposed mechanism is reversing PM2.5-induced EMT through inhibiting TGF-β/Smad3 pathway and then upregulating the expression of tight-junction proteins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ye-fang& Fei, Yu-xiang& Zhao, Bo& Yin, Qi-yang& Zhu, Jian-ping& Ren, Guang-hui…[et al.]. 2020. Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1157179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ye-fang…[et al.]. Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1157179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ye-fang& Fei, Yu-xiang& Zhao, Bo& Yin, Qi-yang& Zhu, Jian-ping& Ren, Guang-hui…[et al.]. Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1157179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر