Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption
Joint Authors
Wang, Ye-fang
Fei, Yu-xiang
Zhao, Bo
Yin, Qi-yang
Zhu, Jian-ping
Ren, Guang-hui
Wang, Bo-wen
Fang, Wei-rong
Li, Yun-man
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This research was designed to explore the effect of Ma Xing Shi Gan decoction (MXD) in alleviating particulate matter less than 2.5 μm in diameter (PM2.5) induced lung injury from the perspective of epithelial barrier protection and inhibition of epithelial-to-mesenchymal transition (EMT).
Rats were exposed to PM2.5 to establish a lung injury model in vivo, and a PM2.5-stimulated primary cultured type II alveolar epithelial cell model was introduced in vitro.
Our results indicated that MXD alleviated the weight loss and pathologic changes and improved the epithelial barrier dysfunction.
MXD also significantly inhibited the TGF-β/Smad3 pathway, increased the level of ZO-1 and claudin-5, and reversed the EMT process.
Notably, the protection of MXD was abolished by TGF-β in vitro.
Our results indicated that MXD has a protection against PM2.5-induced lung injury.
The proposed mechanism is reversing PM2.5-induced EMT through inhibiting TGF-β/Smad3 pathway and then upregulating the expression of tight-junction proteins.
American Psychological Association (APA)
Wang, Ye-fang& Fei, Yu-xiang& Zhao, Bo& Yin, Qi-yang& Zhu, Jian-ping& Ren, Guang-hui…[et al.]. 2020. Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1157179
Modern Language Association (MLA)
Wang, Ye-fang…[et al.]. Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1157179
American Medical Association (AMA)
Wang, Ye-fang& Fei, Yu-xiang& Zhao, Bo& Yin, Qi-yang& Zhu, Jian-ping& Ren, Guang-hui…[et al.]. Ma Xing Shi Gan Decoction Protects against PM2.5-Induced Lung Injury through Suppression of Epithelial-to-Mesenchymal Transition (EMT) and Epithelial Barrier Disruption. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1157179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157179