Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice
المؤلفون المشاركون
Zeng, Zhiyu
Lu, Chuanghong
Chen, Chuanbin
Chen, Ang
Wu, Yunjiao
Wen, Jianlin
Huang, Feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Oridonin (ORI), the major pharmacological component extracted from a traditional Chinese medicine, possesses a beneficial effect on myocardial ischemia/reperfusion (I/R) injury.
However, the underlying molecular mechanism by which ORI effects take place is not completely known.
Thus, whether ORI works via downregulating oxidative stress and nod-like receptor protein-3 (NLRP3) inflammasome pathway was investigated in this study.
Mice underwent surgery to induce myocardial I/R injury, and some were administered ORI (10 mg/kg/day) pretreatment, while others were not.
The myocardial enzymes’ levels, infarct area, and inflammatory injury were measured.
The activation situation of oxidative stress and NLRP3 inflammasome was also detected.
We found that ORI pretreatment significantly alleviated CK-MB and cTnI levels and infarct size induced by I/R.
ORI mitigated the inflammatory injury by decreasing the pathological damage and lowering TNF-α, IL-1β, and IL-18 levels.
Moreover, the SOD1 and eNOS levels were significantly increased by ORI, while MDA and iNOS levels were relatively decreased.
The oxidative stress was reversed using ORI pretreatment.
Importantly, NLRP3 inflammasome pathway was also inhibited by ORI, as reflected by the lower protein levels of NLRP3, caspase-1, and IL-1β.
In conclusion, ORI alleviates myocardial injury induced by I/R via inhibiting the oxidative stress and NLRP3 inflammasome pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Chuanghong& Chen, Chuanbin& Chen, Ang& Wu, Yunjiao& Wen, Jianlin& Huang, Feng…[et al.]. 2020. Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Chuanghong…[et al.]. Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Chuanghong& Chen, Chuanbin& Chen, Ang& Wu, Yunjiao& Wen, Jianlin& Huang, Feng…[et al.]. Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر