Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice
Joint Authors
Zeng, Zhiyu
Lu, Chuanghong
Chen, Chuanbin
Chen, Ang
Wu, Yunjiao
Wen, Jianlin
Huang, Feng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oridonin (ORI), the major pharmacological component extracted from a traditional Chinese medicine, possesses a beneficial effect on myocardial ischemia/reperfusion (I/R) injury.
However, the underlying molecular mechanism by which ORI effects take place is not completely known.
Thus, whether ORI works via downregulating oxidative stress and nod-like receptor protein-3 (NLRP3) inflammasome pathway was investigated in this study.
Mice underwent surgery to induce myocardial I/R injury, and some were administered ORI (10 mg/kg/day) pretreatment, while others were not.
The myocardial enzymes’ levels, infarct area, and inflammatory injury were measured.
The activation situation of oxidative stress and NLRP3 inflammasome was also detected.
We found that ORI pretreatment significantly alleviated CK-MB and cTnI levels and infarct size induced by I/R.
ORI mitigated the inflammatory injury by decreasing the pathological damage and lowering TNF-α, IL-1β, and IL-18 levels.
Moreover, the SOD1 and eNOS levels were significantly increased by ORI, while MDA and iNOS levels were relatively decreased.
The oxidative stress was reversed using ORI pretreatment.
Importantly, NLRP3 inflammasome pathway was also inhibited by ORI, as reflected by the lower protein levels of NLRP3, caspase-1, and IL-1β.
In conclusion, ORI alleviates myocardial injury induced by I/R via inhibiting the oxidative stress and NLRP3 inflammasome pathway.
American Psychological Association (APA)
Lu, Chuanghong& Chen, Chuanbin& Chen, Ang& Wu, Yunjiao& Wen, Jianlin& Huang, Feng…[et al.]. 2020. Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157236
Modern Language Association (MLA)
Lu, Chuanghong…[et al.]. Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157236
American Medical Association (AMA)
Lu, Chuanghong& Chen, Chuanbin& Chen, Ang& Wu, Yunjiao& Wen, Jianlin& Huang, Feng…[et al.]. Oridonin Attenuates Myocardial IschemiaReperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157236