Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis
المؤلفون المشاركون
Lu, Xiaona
Zheng, Yawei
Wen, Fang
Huang, Wenjie
Shu, Peng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-26
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Objectives.
This network meta-analysis (NMA) was designed to assess the comparative effectiveness and safety of oral Chinese patent medicines combined with chemotherapy for gastric cancer on the National Basic Medical Insurance Drugs List of China.
Methods.
A comprehensive literature search was performed in seven electronic databases from their inception to February 25, 2020, aiming to collect all related randomized controlled trials (RCTs) to evaluate the effectiveness and safety of oral Chinese patent medicines as an adjuvant for gastric cancer.
Two researchers independently screened the literature, extracted data, and assessed the risk of bias of included studies using the Cochrane Risk of Bias Scale.
NMA was then performed by using STATA 16.0 software and ADDIS 1.16.8 software.
Results.
Finally, 30 RCTs were included, involving seven kinds of oral Chinese patent medicines, with a total of 2602 patients.
For improvement of clinical efficacy, Bazhen granule combined with chemotherapy was ranked first for effectiveness, followed by the Cinobufacin capsule combined with chemotherapy and Xiao’aiping tablet combined with chemotherapy.
Meanwhile, Bazhen granules combined with chemotherapy also were ranked first in reducing gastrointestinal reactions.
In terms of improving performance status, the Xiao’aiping tablet was the best and significantly better than other oral Chinese patent medicines.
Besides, the Zhenqi Fuzheng granule combined with chemotherapy was best for reducing the incidence of leucopenia.
Conclusions.
Since only one RCT of Bazhen granule was included in this study for analysis, its statistical efficiency is low.
Therefore, this study recommends that the Cinobufacin capsule combined with chemotherapy should be a priority in improving clinical efficacy.
In terms of improving patients’ quality of life, Xiao’aiping tablet is the best choice.
Safety was best for Zhenqi Fuzheng granule and Bazhen granule combined with chemotherapy.
Limited by the quantity, quality, and possible bias of included studies, the above conclusions need to be further verified by more high-quality RCTs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Xiaona& Zheng, Yawei& Wen, Fang& Huang, Wenjie& Shu, Peng. 2020. Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1157382
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Xiaona…[et al.]. Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1157382
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Xiaona& Zheng, Yawei& Wen, Fang& Huang, Wenjie& Shu, Peng. Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1157382
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157382
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر