Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis
Joint Authors
Lu, Xiaona
Zheng, Yawei
Wen, Fang
Huang, Wenjie
Shu, Peng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Objectives.
This network meta-analysis (NMA) was designed to assess the comparative effectiveness and safety of oral Chinese patent medicines combined with chemotherapy for gastric cancer on the National Basic Medical Insurance Drugs List of China.
Methods.
A comprehensive literature search was performed in seven electronic databases from their inception to February 25, 2020, aiming to collect all related randomized controlled trials (RCTs) to evaluate the effectiveness and safety of oral Chinese patent medicines as an adjuvant for gastric cancer.
Two researchers independently screened the literature, extracted data, and assessed the risk of bias of included studies using the Cochrane Risk of Bias Scale.
NMA was then performed by using STATA 16.0 software and ADDIS 1.16.8 software.
Results.
Finally, 30 RCTs were included, involving seven kinds of oral Chinese patent medicines, with a total of 2602 patients.
For improvement of clinical efficacy, Bazhen granule combined with chemotherapy was ranked first for effectiveness, followed by the Cinobufacin capsule combined with chemotherapy and Xiao’aiping tablet combined with chemotherapy.
Meanwhile, Bazhen granules combined with chemotherapy also were ranked first in reducing gastrointestinal reactions.
In terms of improving performance status, the Xiao’aiping tablet was the best and significantly better than other oral Chinese patent medicines.
Besides, the Zhenqi Fuzheng granule combined with chemotherapy was best for reducing the incidence of leucopenia.
Conclusions.
Since only one RCT of Bazhen granule was included in this study for analysis, its statistical efficiency is low.
Therefore, this study recommends that the Cinobufacin capsule combined with chemotherapy should be a priority in improving clinical efficacy.
In terms of improving patients’ quality of life, Xiao’aiping tablet is the best choice.
Safety was best for Zhenqi Fuzheng granule and Bazhen granule combined with chemotherapy.
Limited by the quantity, quality, and possible bias of included studies, the above conclusions need to be further verified by more high-quality RCTs.
American Psychological Association (APA)
Lu, Xiaona& Zheng, Yawei& Wen, Fang& Huang, Wenjie& Shu, Peng. 2020. Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1157382
Modern Language Association (MLA)
Lu, Xiaona…[et al.]. Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1157382
American Medical Association (AMA)
Lu, Xiaona& Zheng, Yawei& Wen, Fang& Huang, Wenjie& Shu, Peng. Effectiveness and Safety of Oral Chinese Patent Medicines Combined with Chemotherapy for Gastric Cancer: A Bayesian Network Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1157382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157382