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Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica
المؤلفون المشاركون
Su, Dan
Huang, Yun
Liao, Zhou
Li, Shanshan
Luo, Xiaoquan
Zhong, Youbao
Ji, Yanhua
Ai, Zhifu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Ephedra sinica Stapf (EP) has a long medication history dating back centuries in the world.
There were some reports of adverse effects in the central nervous system (CNS) resulting from administration of a drug containing EP or ephedrine.
Compared with alkaloid monomer compounds, the effects of EP on the CNS are usually neglected.
It is necessary to explore CNS affection which is helpful to use EP rationally.
However, the affection and the changes of substances by EP in the brain are still unknown because the effects of drug on the brain also exhibit different tendency and distribution and usually lead to diversity of metabolite alteration in different regions.
In this study, metabolomics based on different brain regions was used to investigate the affection mechanism of EP in the CNS.
The metabolites in 6 brain regions from a rat that underwent oral administration with EP for 14 days were determined by UPLC/Q-TOF-MS.
Brain histological examinations showed that there were no obvious lesions in EP administration groups.
Partial least square-discriminant analysis (PLS-DA) displayed that there were significant separations between control and EP administration groups.
7 CNS biomarkers were found and identified in different regions.
3 metabolic pathways were disturbed by EP, including amino acid metabolism, phospholipid metabolism, and amino sugar metabolism.
Furthermore, all biomarkers were significantly changed in the cortex after administration.
This study may be helpful to understand the affection mechanism of EP in the CNS and improve cognition of brain regional characteristics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liao, Zhou& Li, Shanshan& Huang, Yun& Luo, Xiaoquan& Zhong, Youbao& Ji, Yanhua…[et al.]. 2020. Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157518
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liao, Zhou…[et al.]. Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157518
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liao, Zhou& Li, Shanshan& Huang, Yun& Luo, Xiaoquan& Zhong, Youbao& Ji, Yanhua…[et al.]. Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157518
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157518
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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