Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica

Joint Authors

Su, Dan
Huang, Yun
Liao, Zhou
Li, Shanshan
Luo, Xiaoquan
Zhong, Youbao
Ji, Yanhua
Ai, Zhifu

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-04-27

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Ephedra sinica Stapf (EP) has a long medication history dating back centuries in the world.

There were some reports of adverse effects in the central nervous system (CNS) resulting from administration of a drug containing EP or ephedrine.

Compared with alkaloid monomer compounds, the effects of EP on the CNS are usually neglected.

It is necessary to explore CNS affection which is helpful to use EP rationally.

However, the affection and the changes of substances by EP in the brain are still unknown because the effects of drug on the brain also exhibit different tendency and distribution and usually lead to diversity of metabolite alteration in different regions.

In this study, metabolomics based on different brain regions was used to investigate the affection mechanism of EP in the CNS.

The metabolites in 6 brain regions from a rat that underwent oral administration with EP for 14 days were determined by UPLC/Q-TOF-MS.

Brain histological examinations showed that there were no obvious lesions in EP administration groups.

Partial least square-discriminant analysis (PLS-DA) displayed that there were significant separations between control and EP administration groups.

7 CNS biomarkers were found and identified in different regions.

3 metabolic pathways were disturbed by EP, including amino acid metabolism, phospholipid metabolism, and amino sugar metabolism.

Furthermore, all biomarkers were significantly changed in the cortex after administration.

This study may be helpful to understand the affection mechanism of EP in the CNS and improve cognition of brain regional characteristics.

American Psychological Association (APA)

Liao, Zhou& Li, Shanshan& Huang, Yun& Luo, Xiaoquan& Zhong, Youbao& Ji, Yanhua…[et al.]. 2020. Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157518

Modern Language Association (MLA)

Liao, Zhou…[et al.]. Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157518

American Medical Association (AMA)

Liao, Zhou& Li, Shanshan& Huang, Yun& Luo, Xiaoquan& Zhong, Youbao& Ji, Yanhua…[et al.]. Metabolite Profile Changes in Different Regions of Rat Brain Affected by Ephedra sinica. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157518

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1157518