Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry
المؤلفون المشاركون
Galvez, Julio
Bribi, Noureddine
Gómez-Caravaca, Ana María
Segura-Carretero, Antonio
Contreras, María del Mar
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-28
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Two analytical platforms, gas chromatography (GC) coupled to quadrupole-time-of-flight (QTOF) mass spectrometry (MS) and reversed-phase ultrahigh performance liquid chromatography (UHPLC) coupled to diode array (DAD) and QTOF detection, were applied in order to study the alkaloid profile of Fumaria capreolata.
The use of these mass analyzers enabled tentatively identifying the alkaloids by matching their accurate mass signals and suggested molecular formulae with those previously reported in libraries and databases.
Moreover, the proposed structures were corroborated by studying their fragmentation pattern obtained by both platforms.
In this way, 8 and 26 isoquinoline alkaloids were characterized using GC-QTOF-MS and RP-UHPLC-DAD-QTOF-MS, respectively, and they belonged to the following subclasses: protoberberine, protopine, aporphine, benzophenanthridine, spirobenzylisoquinoline, morphinandienone, and benzylisoquinoline.
Moreover, the latter analytical method was selected to determine at 280 nm the concentration of protopine (9.6 ± 0.7 mg/g), a potential active compound of the extract.
In conclusion, although GC-MS has been commonly used for the analysis of this type of phytochemicals, RP-UHPLC-DAD-QTOF-MS provided essential complementary information.
This analytical method can be applied for the quality control of phytopharmaceuticals containing Fumaria extracts currently found in the market.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Contreras, María del Mar& Bribi, Noureddine& Gómez-Caravaca, Ana María& Galvez, Julio& Segura-Carretero, Antonio. 2017. Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry. International Journal of Analytical Chemistry،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1157575
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Contreras, María del Mar…[et al.]. Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry. International Journal of Analytical Chemistry No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1157575
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Contreras, María del Mar& Bribi, Noureddine& Gómez-Caravaca, Ana María& Galvez, Julio& Segura-Carretero, Antonio. Alkaloids Profiling of Fumaria capreolata by Analytical Platforms Based on the Hyphenation of Gas Chromatography and Liquid Chromatography with Quadrupole-Time-of-Flight Mass Spectrometry. International Journal of Analytical Chemistry. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1157575
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157575
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر