Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity
المؤلفون المشاركون
Xiao, Wei
Zheng, Weiran
Li, Meng
Wang, Yongxiang
Lv, Baojie
Zhang, Xinzhuang
Chen, Lilan
Zhu, Kejin
Wang, Zhenzhong
Li, Baoxin
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Guizhi Fuling capsule (GZFLc) is a modern preparation from traditional Chinese Medicine.
Guizhi Fuling was first prescribed by Zhang Zhongjing almost two thousand years ago for the treatment of primary dysmenorrhea.
It has also been used to treat uterine fibroids, dysfunctional uterine bleeding, and endometriosis.
Although effective against dysmenorrhea clinically, there are limited information on the mechanism of its action.
The major components responsible for the activity are not well defined.
The aim of this study has been to elucidate a mechanism that may facilitate the development of a bioactivity-based assay for quality control during drug formulation and manufacturing.
Using an oxytocin-induced mouse dysmenorrhea model, we showed that oral administration of GZFLc at 150 and 300 mg/kg, dosages relevant to clinic usages, significantly suppressed oxytocin-induced writhing response.
The antidysmenorrhea effect was also demonstrated by a rotarod assay.
We showed that GZFLc treatment significantly prolonged the hanging time of mice on the rotating rod.
Histological studies showed that GZFLc treatment reduced lamina propria edema, while no effect on COX2 expression was detected.
GZFLc instead exhibited direct inhibitory effect against COX2, a critical enzyme that catalyzes arachidonic acid conversion to prostaglandins.
By HPLC profiling, we showed that paeoniflorin, paeonol, and cinnamaldehyde are the major components from the corresponding plants.
At 5 and 10 mg/kg, both paeoniflorin and paeonol were active against induced dysmenorrhea.
The study not only links GZFLc antidysmenorrhea activity to COX2 inhibition but also uncovers a mechanism of action by which an assay can be developed for bioefficacy evaluation of GZFLc.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Weiran& Li, Meng& Wang, Yongxiang& Lv, Baojie& Zhang, Xinzhuang& Chen, Lilan…[et al.]. 2020. Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157767
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Weiran…[et al.]. Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157767
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Weiran& Li, Meng& Wang, Yongxiang& Lv, Baojie& Zhang, Xinzhuang& Chen, Lilan…[et al.]. Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157767
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157767
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر