Genome-Wide Regulation of Electroacupuncture and Treadmill Exercise on Diet-Induced Obese Rats
المؤلفون المشاركون
Wei, Dan
Mo, Guoyan
Zhang, Yanji
Li, Jia
Yu, Chaochao
Wang, Lihua
Zhuo, Yue
Xu, Kou
Zhang, Yingrong
Xue, Yixuan
Huang, Wei
Zhou, Zhongyu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Acupuncture has been widely used for obesity treatment, but its mechanism is still unclear.
To investigate the molecular mechanisms, we applied electroacupuncture (EA) at the Zusanli (ST36) acupoint and treadmill exercise (TE) in a diet-induced obese (DIO) rat model and used RNA sequencing (RNA-seq) to identify molecular consequences.
Forty Sprague-Dawley male rats were selected and randomly divided into five groups: control (C), DIO model (M), EA, TE, and EA + TE groups.
According to the results, acupuncture reduced body weight and the ratio of retroperitoneal white adipose tissue (retro-WAT) to body weight.
Total RNA was extracted from the retro-WAT from five groups for RNA-seq.
Differentially expressed genes (DEG) analysis showed that there were obvious differences among the four comparisons of C vs.
M, M vs.
EA, M vs.
TE, and M vs.
EA + TE, followed by 1383, 913, 3324, and 2794 DE genes.
Gene ontology (GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed to further classify the DEGs.
Several GO terms were commonly significantly enriched in both M vs.
TE and M vs.
EA, such as myofibril and muscle contraction.
In addition, some pathways were regulated by EA and TE, such as the peroxisome proliferator activated receptor signaling pathway and calcium signaling pathway.
This study is the first to compare and analyze the differences in gene expression profiles in the retro-WAT of rats in different groups, which provide a clue for further investigation into the molecular mechanisms of obesity treatment by EA and TE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yanji& Li, Jia& Wei, Dan& Mo, Guoyan& Yu, Chaochao& Wang, Lihua…[et al.]. 2020. Genome-Wide Regulation of Electroacupuncture and Treadmill Exercise on Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157947
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yanji…[et al.]. Genome-Wide Regulation of Electroacupuncture and Treadmill Exercise on Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1157947
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yanji& Li, Jia& Wei, Dan& Mo, Guoyan& Yu, Chaochao& Wang, Lihua…[et al.]. Genome-Wide Regulation of Electroacupuncture and Treadmill Exercise on Diet-Induced Obese Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1157947
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1157947
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر