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In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia
المؤلفون المشاركون
Farooq, Muhammad
Alqahtani, Ali S.
Ullah, Riaz
Noman, Omar M.
Nasr, Fahd A
Herqash, Rashed N.
Alyhya, Nouf
Anazi, Shamsa H.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Current treatments for complex diseases have remarkable side effects that negatively impact patients’ quality of life.
Thus, natural compounds with fewer side effects represent a promising source for safe drugs.
The genus Senecio is widely used in folk medicine due to its various pharmacological properties.
In the present study, the total phenolic content of Senecio glaucus, which is grown in Saudi Arabia, was assessed using the Folin-Ciocalteau colorimetric method.
Scavenging DPPH and ABTS assays were utilized to determine the antioxidant properties of S.
glaucus fractions, and MTT assay was used to screen the cytotoxic activity of S.
glaucus against various cancer cells.
In addition, HPLC-UV was utilized to detect the presence of two phenolic acids, namely, vanillic acid (VA) and gallic acid (GA).
Among all fractions tested, S.
glaucus chloroform fraction (SGCF) yielded the highest value (125.3 mg·GA/g) in terms of total phenolic content.
SGCF also exhibited the highest scavenging activities (76.7 and 74.1%) on both DPPH and ABTS assays, respectively.
Similarly, SGCF also possessed the most potent cytotoxic activity against the MCF-7 cell line, with an IC50 value of 41.8 μg/ml.
The validated HPLC method confirmed the presence of VA (4.8 μg/mg DW) and GA (3.9 μg/mg DW) in SGCF.
Overall, our data show that S.
glaucus had antioxidant and cytotoxic properties.
A developed validated HPLC method which could be helpful for quantifying phenolic compounds in S.
glaucus was established.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alqahtani, Ali S.& Herqash, Rashed N.& Noman, Omar M.& Nasr, Fahd A& Alyhya, Nouf& Anazi, Shamsa H.…[et al.]. 2020. In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alqahtani, Ali S.…[et al.]. In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alqahtani, Ali S.& Herqash, Rashed N.& Noman, Omar M.& Nasr, Fahd A& Alyhya, Nouf& Anazi, Shamsa H.…[et al.]. In Vitro Antioxidant, Cytotoxic Activities, and Phenolic Profile of Senecio glaucus from Saudi Arabia. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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