Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction
المؤلفون المشاركون
Zhu, Zhaojin
Zhang, Wenyi
Xie, Bin
Yang, Yujie
Cheng, Jie
Zhang, Yongni
Guo, Jiabao
Zhu, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Electroacupuncture (EA) could improve colonic transit activity in rats with neurogenic bowel dysfunction (NBD) caused by spinal cord injury (SCI).
The function of interstitial cells of Cajal (ICCs) and c-Kit expression may play essential roles in this process.
Material and Methods.
Thirty-six Sprague Dawley rats were randomized to the sham group, the SCI group, or the SCI + EA group (bilateral Zusanli, 30 min/day, 14 days).
Changes in the ultrastructural morphology of ICCs were observed.
The c-Kit expression on different levels was analyzed by immunohistochemistry, Western blotting, and RT-qPCR, respectively.
Results.
Abnormal morphology of ICCs and downregulation of the c-Kit expression occurred after SCI.
While the number of ICCs was increased, the ultrastructural morphology was improved significantly in EA rats.
They also showed better improvement in c-Kit expression at both protein and gene levels.
Conclusion.
Abnormal ICCs in colon tissues and the downregulated expression of c-Kit could be observed after SCI.
EA at Zusanli (ST36) could improve the colon function by repairing the morphology and increasing the number of ICCs and upregulating c-Kit expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Yujie& Cheng, Jie& Zhang, Yongni& Guo, Jiabao& Xie, Bin& Zhang, Wenyi…[et al.]. 2020. Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Yujie…[et al.]. Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Yujie& Cheng, Jie& Zhang, Yongni& Guo, Jiabao& Xie, Bin& Zhang, Wenyi…[et al.]. Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c-Kit Expression in Rats with SCI-Induced Neurogenic Bowel Dysfunction. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1158229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر